Heterotypic Cellular Interactions in the Ovarian Tumor Microenvironment: Biological Significance and Therapeutic Implications

Biological Significance of Apoptosis in Ovarian Cancer: TRAIL Therapeutic Targeting

Cancer Microenvironment and Therapeutic Implications

Since the seminal work it is known that inflammation is a major risk factor for cancer. Inflammation can be caused by agents as diverse as heat, cold, foreign body or chemicals. In every case, there is a protein leak from the damaged capillaries. This results in increased oncotic pressure which is in turn responsible for the methylation of the PP2A phosphatase. The activation of PP2A results in...

Immune Cell Population in Ovarian Tumor Microenvironment

Ovarian cancer, the third most common with highest mortality rates gynecological malignancy among women in China, is characterized by a unique tumor immune microenvironment. Immune-cell population infiltrated into the tumor tissue among patients with ovarian cancer are associated positively or negatively with antitumor activity. The imbalance between immune activation and immune suppression can...

Interactions between the epidermal growth factor receptor and type I protein kinase A: biological significance and therapeutic implications.

Peptide growth factors regulate normal cellular proliferation and differentiation through autocrine and paracrine pathways and are involved in cancer development and progression. Among the endogenous growth factors, the epidermal growth factor (EGF)-related proteins play an important role in the pathogenesis of human cancer. In fact, overexpression of EGF-related growth factors such as transfor...

Rho-associated kinase signalling and the cancer microenvironment: novel biological implications and therapeutic opportunities

The Rho/ROCK pathway is involved in numerous pivotal cellular processes that have made it an area of intense study in cancer medicine, however, Rho-associated coiled-coil containing protein kinase (ROCK) inhibitors are yet to make an appearance in the clinical cancer setting. Their performance as an anti-cancer therapy has been varied in pre-clinical studies, however, they have been shown to be...